GHK-Cu

Overview

GHK-Cu is a naturally occurring copper-binding tripeptide first isolated from human plasma by Dr. Loren Pickart in 1973. The tripeptide glycyl-L-histidyl-L-lysine has a strong affinity for copper(II) ions, forming a complex that has been the subject of extensive research in wound biology, dermatology, and tissue remodeling.

Research Summary

GHK-Cu has been studied in multiple in vitro and animal model systems. Research has examined its effects on collagen synthesis in fibroblast cultures (Pickart et al., 2015), extracellular matrix remodeling, and its interaction with metalloproteinase activity. Dermatological research has investigated its role in skin remodeling processes. Gene expression studies suggest GHK-Cu may modulate hundreds of genes involved in tissue repair and inflammatory responses. Research contexts include wound biology, dermatological science, and cosmetic chemistry.

Proposed Mechanism of Action

GHK-Cu is understood to facilitate copper delivery to cellular systems, activating copper-dependent enzymes including superoxide dismutase and lysyl oxidase. In vitro research indicates it may modulate TGF-β signaling, promote decorin expression, and influence gene expression patterns associated with tissue remodeling.

Vendor Availability

Published Research References

References are provided for informational purposes. PeptiNox does not endorse or validate the conclusions of cited studies. All listed research pertains to preclinical or in vitro investigations unless otherwise noted.