Overview
TB-500 is a synthetic analog of Thymosin Beta-4, a 43-amino acid naturally occurring peptide present in virtually all human and animal cells. TB-500 replicates the active region of Thymosin Beta-4 responsible for actin binding and cell migration signaling. It is one of the most widely studied peptides in veterinary and preclinical research contexts.
Research Summary
Thymosin Beta-4 and its synthetic analogs have been studied extensively in animal models for tissue repair processes. Research in equine models examined recovery from tendon and ligament injuries. Rodent studies have investigated cardiac tissue repair following ischemic events (Bock-Marquette et al., 2004), dermal wound healing, and inflammatory response modulation. In vitro studies have documented its role in actin sequestration and its effects on endothelial cell migration. All referenced research is preclinical.
Proposed Mechanism of Action
TB-500 is understood to function primarily through its interaction with G-actin, promoting actin polymerization and cellular migration. Preclinical research indicates it may upregulate cell-surface receptors involved in extracellular matrix remodeling and promote angiogenic signaling through VEGF pathway modulation.
Vendor Availability
| Vendor | Status | Price (from) | Sizes |
|---|---|---|---|
| Ascension Peptides | Verified | $54.99 | 2mg, 5mg |
| Swiss Chems | Verified | $49.99 | 2mg, 5mg, 10mg |
| Core Peptides | Verified | $52.99 | 5mg |
| Limitless Biotech | Verified | $59.99 | 2mg, 5mg |
| Sports Technology Labs | Verified | $51.99 | 2mg, 5mg |
| Amino Asylum | Pending | $39.99 | 2mg, 5mg, 10mg |
| Bioinfinity | Pending | $44.99 | 2mg, 5mg |
Published Research References
Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Nature (2004)
DOI: 10.1038/nature02517
Thymosin beta 4 promotes dermal healing
Annals of the New York Academy of Sciences (2007)
DOI: 10.1196/annals.1389.013
Thymosin β4: roles in development, repair, and engineering of the cardiovascular system
Annals of the New York Academy of Sciences (2012)
DOI: 10.1111/j.1749-6632.2012.06633.x
References are provided for informational purposes. PeptiNox does not endorse or validate the conclusions of cited studies. All listed research pertains to preclinical or in vitro investigations unless otherwise noted.
Molecular Data
- Sequence
- Ac-SDKP (N-terminal active domain: LKKTETQ)
- Molecular Weight
- 4963.44 g/mol
- Formula
- C212H350N56O78S
- CAS Number
- 77591-33-4
- Purity
- ≥98%
Storage & Handling
Storage
Store lyophilized peptide at -20°C. Protect from light. Reconstituted solution stable at 4°C for up to 10 days.
Solubility
Soluble in sterile water or bacteriostatic water.
Research Use Only. All products listed on PeptiNox are intended solely for laboratory research and scientific investigation. Not for human consumption, therapeutic use, or any application in humans or animals outside of approved research protocols. PeptiNox is an independent verification platform and does not sell, distribute, or manufacture any research compounds.