Overview
CJC-1295 is a synthetic 29-amino acid peptide analog of growth hormone-releasing hormone (GHRH). The modified version (Mod GRF 1-29) incorporates four amino acid substitutions to enhance metabolic stability while preserving receptor binding affinity at the GHRH receptor. It is one of the most widely studied growth hormone secretagogue peptides in research settings.
Research Summary
CJC-1295 has been studied in preclinical and early clinical research contexts for its effects on growth hormone secretion patterns. Research in animal models has examined its pharmacokinetic profile, pulsatile GH release characteristics, and effects on IGF-1 levels. Studies have investigated both the DAC (Drug Affinity Complex) and non-DAC versions, with the non-DAC variant (Mod GRF 1-29) being more commonly used in current research. Early-phase clinical studies documented sustained GH elevation and favorable pharmacokinetic properties.
Proposed Mechanism of Action
CJC-1295 acts as a GHRH receptor agonist, binding to the GHRH receptor on anterior pituitary somatotroph cells. This binding stimulates adenylyl cyclase activation, cAMP production, and subsequent growth hormone synthesis and release. The modified amino acids at positions 2, 8, 15, and 27 confer resistance to DPP-IV enzymatic cleavage.
Vendor Availability
| Vendor | Status | Price (from) | Sizes |
|---|---|---|---|
| Ascension Peptides | Verified | $39.99 | 2mg, 5mg |
| Swiss Chems | Verified | $36.99 | 2mg, 5mg |
| Limitless Biotech | Verified | $44.99 | 2mg, 5mg |
| Sports Technology Labs | Verified | $37.99 | 2mg, 5mg |
| Amino Asylum | Pending | $29.99 | 2mg, 5mg, 10mg |
| Bioinfinity | Pending | $33.99 | 2mg, 5mg |
Published Research References
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295
Journal of Clinical Endocrinology & Metabolism (2006)
DOI: 10.1210/jc.2005-1536
GH-releasing peptides — past, present, and future
Endocrine Reviews (2005)
DOI: 10.1210/er.2004-0025
References are provided for informational purposes. PeptiNox does not endorse or validate the conclusions of cited studies. All listed research pertains to preclinical or in vitro investigations unless otherwise noted.
Molecular Data
- Sequence
- Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg
- Molecular Weight
- 3367.97 g/mol
- Formula
- C152H252N44O42
- CAS Number
- 863288-34-0
- Purity
- ≥98%
Storage & Handling
Storage
Store lyophilized peptide at -20°C. Reconstituted solutions at 4°C, use within 14 days.
Solubility
Soluble in sterile water or bacteriostatic water.
Research Use Only. All products listed on PeptiNox are intended solely for laboratory research and scientific investigation. Not for human consumption, therapeutic use, or any application in humans or animals outside of approved research protocols. PeptiNox is an independent verification platform and does not sell, distribute, or manufacture any research compounds.