Overview
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue and ghrelin receptor (GHS-R1a) agonist. It is distinguished from other GH secretagogues by its high selectivity for GH release without significant effects on cortisol or prolactin levels in preclinical studies. This selectivity profile has made it one of the most widely used peptides in growth hormone research.
Research Summary
Preclinical research on Ipamorelin has documented its selective GH-releasing properties with minimal effects on other pituitary hormones. Studies in rodent and porcine models have characterized its pharmacokinetic profile, dose-response curves, and interaction with the GHS-R1a receptor. Research has examined its effects on bone mineral density in ovariectomized rat models and its potential synergistic effects when combined with GHRH analogs. Ipamorelin is frequently studied in combination with CJC-1295 in research protocols.
Proposed Mechanism of Action
Ipamorelin binds to the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotroph cells, triggering intracellular calcium signaling and subsequent GH release. Unlike GHRP-6 or hexarelin, Ipamorelin demonstrates high selectivity for GH release without significant activation of cortisol, prolactin, or ACTH secretion pathways.
Vendor Availability
| Vendor | Status | Price (from) | Sizes |
|---|---|---|---|
| Ascension Peptides | Verified | $36.99 | 2mg, 5mg |
| Swiss Chems | Verified | $34.99 | 2mg, 5mg |
| Limitless Biotech | Verified | $42.99 | 2mg, 5mg |
| Sports Technology Labs | Verified | $35.99 | 2mg, 5mg |
| Amino Asylum | Pending | $27.99 | 2mg, 5mg, 10mg |
| Bioinfinity | Pending | $31.99 | 2mg, 5mg |
Published Research References
Ipamorelin, the first selective growth hormone secretagogue
European Journal of Endocrinology (1999)
DOI: 10.1530/eje.0.1400643
The effect of ipamorelin on bone and body composition in ovariectomized rats
Bone (2000)
DOI: 10.1016/S8756-3282(00)00325-8
References are provided for informational purposes. PeptiNox does not endorse or validate the conclusions of cited studies. All listed research pertains to preclinical or in vitro investigations unless otherwise noted.
Molecular Data
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH₂
- Molecular Weight
- 711.85 g/mol
- Formula
- C38H49N9O5
- CAS Number
- 170851-70-4
- Purity
- ≥98%
Storage & Handling
Storage
Store lyophilized peptide at -20°C. Reconstituted solutions at 4°C.
Solubility
Soluble in sterile water or bacteriostatic water.
Research Use Only. All products listed on PeptiNox are intended solely for laboratory research and scientific investigation. Not for human consumption, therapeutic use, or any application in humans or animals outside of approved research protocols. PeptiNox is an independent verification platform and does not sell, distribute, or manufacture any research compounds.