Overview
Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-10) with an added Pro-Gly-Pro C-terminal sequence for enhanced metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences alongside Selank, Semax has been investigated in preclinical research for its neurotrophic and neuroprotective properties.
Research Summary
Preclinical studies on Semax have focused on its neurotrophic properties, including upregulation of BDNF and TrkB receptor expression in rodent brain tissue. Research has examined its effects on neuronal survival in ischemic models, gene expression changes in the hippocampus and prefrontal cortex, and modulation of dopaminergic and serotonergic systems. In vitro studies have documented its effects on neurite outgrowth and neuronal differentiation. Semax is registered as a pharmaceutical agent in Russia for specific indications but has not been evaluated by the FDA.
Proposed Mechanism of Action
Semax is proposed to act through melanocortin receptor subtypes (MC4R, MC3R) while also independently modulating neurotrophic factor expression. Research indicates it upregulates BDNF/TrkB signaling, influences cholinergic and dopaminergic neurotransmission, and may modulate gene expression patterns involved in synaptic plasticity and neuronal survival.
Vendor Availability
| Vendor | Status | Price (from) | Sizes |
|---|---|---|---|
| Core Peptides | Verified | $38.99 | 5mg |
| Apollo Peptide Sciences | Verified | $42.99 | 5mg, 10mg |
| Bioinfinity | Pending | $34.99 | 5mg |
Published Research References
Semax, an ACTH(4-10) analogue with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Brain Research (2005)
DOI: 10.1016/j.brainres.2005.05.048
Neuroprotective effect of Semax in acute period of ischemic stroke
Zhurnal Nevrologii i Psikhiatrii (2006)
DOI: 10.1007/s10517-006-0009-9
References are provided for informational purposes. PeptiNox does not endorse or validate the conclusions of cited studies. All listed research pertains to preclinical or in vitro investigations unless otherwise noted.
Molecular Data
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular Weight
- 813.93 g/mol
- Formula
- C37H51N9O10S
- CAS Number
- 80714-61-0
- Purity
- ≥98%
Storage & Handling
Storage
Store at -20°C. Protect from light and moisture. Reconstituted solutions at 4°C.
Solubility
Soluble in sterile water or bacteriostatic water.
Research Use Only. All products listed on PeptiNox are intended solely for laboratory research and scientific investigation. Not for human consumption, therapeutic use, or any application in humans or animals outside of approved research protocols. PeptiNox is an independent verification platform and does not sell, distribute, or manufacture any research compounds.